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HRS-4642
KRAS G12D inhibitor
HRS-4642 is a selective KRAS^G12D inhibitor with a dissociation constant (Kd) of 0.083 nM, demonstrating potent anti-cancer activity. It synergizes with Carfilzomib and exhibits strong in vivo efficacy, promoting remodeling of the tumor microenvironment into an immune-activating state.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2836263-09-1 |
| Applications | KRAS G12D inhibitor |
| Formula | C34H35F3N6O3 |
| Molecular Weight | 632.68 |
| SMILES | OC(C=C1C2=C(F)C(N=C(OC[C@@]3(CCC4)N4C[C@H](F)C3)N=C5N(C[C@@H]6N[C@H]7CC6)[C@@H]7CO8)=C5C8=N2)=CC9=C1C(CC)=C(F)C=C9 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.