Fig. 1 · Structure

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HSD17B13-IN-18

Cat. No. A69096 CAS 2758802-14-9

17β-HSD Inhibitor

HSD17B13-IN-18 is a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 of less than 0.1 μM for estradiol and less than 1 μM for Leukotriene B3. This compound is significant in the context of nonalcoholic fatty liver diseases (NAFLDs), particularly in the study of nonalcoholic steatohepatitis (NASH). HSD17B13-IN-18 facilitates research aimed at understanding and potentially therapeutically targeting metabolic disorders related to liver function.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 2758802-14-9
Applications 17β-HSD Inhibitor
Formula C21H19ClN2O4S
Molecular Weight 430.90
SMILES
ClC1=CC(C(NC2=C(C(NCCC3=C(OC)C=CC=C3)=O)C=CS2)=O)=CC=C1O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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