HSD17B13-IN-24

Catalog No.: A69072
HSD17B13 Inhbitor
HSD17B13-IN-24 is a potent inhibitor of 17β-Hydroxysteroid dehydrogenases (HSD17B13) with an IC50 value of less than 0.1 μM for estradiol. This compound is primarily utilized in research related to nonalcoholic fatty liver disease (NAFLD), facilitating the understanding of metabolic pathways and potential therapeutic targets in liver disorders. Its high specificity makes it a valuable tool for investigating the role of HSD17B13 in various biological contexts.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionHSD17B13-IN-24 is a potent inhibitor of 17β-Hydroxysteroid dehydrogenases (HSD17B13) with an IC50 value of less than 0.1 μM for estradiol. This compound is primarily utilized in research related to nonalcoholic fatty liver disease (NAFLD), facilitating the understanding of metabolic pathways and potential therapeutic targets in liver disorders. Its high specificity makes it a valuable tool for investigating the role of HSD17B13 in various biological contexts.
Product Information
Catalog NumA69072
FormulaC22H15Cl2FN4O3
Molecular Weight473.28
CAS Number2770246-37-0
SMILESO=C(C1=CC(Cl)=C(C(Cl)=N1)O)NC2=C3C(N=CN(C3=O)[C@H](C4=CC(F)=CC=C4)C)=CC=C2
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