HSD17B13-IN-62

Catalog No.: A69020
HSD17B13 Inhbitor
HSD17B13-IN-62 is a potent inhibitor of 17β-Hydroxysteroid dehydrogenases (HSD17B13), demonstrating an IC50 of less than 0.1 μM for estradiol. This compound is primarily utilized in research related to nonalcoholic fatty liver diseases (NAFLD), providing valuable insights into the mechanisms of lipid metabolism and hormone regulation. Its application may aid in the development of therapeutic strategies targeting liver dysfunction and associated metabolic disorders.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
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Nature volume 574, pages268-272 (2019)
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Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
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Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionHSD17B13-IN-62 is a potent inhibitor of 17β-Hydroxysteroid dehydrogenases (HSD17B13), demonstrating an IC50 of less than 0.1 μM for estradiol. This compound is primarily utilized in research related to nonalcoholic fatty liver diseases (NAFLD), providing valuable insights into the mechanisms of lipid metabolism and hormone regulation. Its application may aid in the development of therapeutic strategies targeting liver dysfunction and associated metabolic disorders.
Product Information
Catalog NumA69020
FormulaC24H17Cl2F3N4O4
Molecular Weight553.32
CAS Number2770247-32-8
SMILESO=C(C1=NC(Cl)=C(C(Cl)=C1)O)NC(C=CC(C)=C2N=C(C)N3CC4=C(OC(F)(F)F)C=CC=C4)=C2C3=O
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