HSD17B13-IN-97

Catalog No.: A69006
HSD17B13 Inhibitor
HSD17B13-IN-97 is a highly potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of ≤0.1 µM. This compound holds promise for investigating therapeutic strategies for nonalcoholic fatty liver diseases (NAFLDs), nonalcoholic steatohepatitis (NASH), and drug-induced liver injury (DILI). Its selective inhibition of HSD17B13 makes it a valuable tool for exploring lipid metabolism and liver pathology in preclinical research.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionHSD17B13-IN-97 is a highly potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of ≤0.1 µM. This compound holds promise for investigating therapeutic strategies for nonalcoholic fatty liver diseases (NAFLDs), nonalcoholic steatohepatitis (NASH), and drug-induced liver injury (DILI). Its selective inhibition of HSD17B13 makes it a valuable tool for exploring lipid metabolism and liver pathology in preclinical research.
Product Information
Catalog NumA69006
FormulaC22H14F4N4O3
Molecular Weight458.37
CAS Number2849338-44-7
SMILESOC1=C(C(F)(F)F)N=C(C(NC2=CC=CC(N=CN3CC4=CC=CC=C4F)=C2C3=O)=O)C=C1
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