Fig. 1 · Structure
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hSMG-1 inhibitor 11e
hSMG-1 Inhibitor
hSMG-1 inhibitor 11e is a highly selective inhibitor of the hSMG-1 kinase, exhibiting an impressive IC50 of less than 0.05 nM. This compound demonstrates over 900-fold selectivity against mTOR, along with significant selectivity over PI3Kα/γ and CDK1/CDK2, making it a valuable tool for probing the roles of hSMG-1 in cellular processes. It is suitable for research applications focused on cancer biology, RNA surveillance mechanisms, and potential therapeutic strategies targeting the DNA damage response.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1402452-10-1 |
| Applications | hSMG-1 Inhibitor |
| Formula | C26H27N7O3S |
| Molecular Weight | 517.60 |
| SMILES | O=S(C1=CC(NC2=NC=CC(C3=CC(C4=CC=C(NC(NC)=O)C=C4)=NC=C3)=N2)=CC=C1C)(N(C)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.