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HSN608

RET G810 Mutant Inhibitor

HSN608 is a potent inhibitor of the RET G810 mutant, specifically targeting the G810C, G810R, and G810D variants. This orally active compound induces apoptosis in RET-altered cells and exhibits efficacy against Selpercatinib-resistant RET(G810C) CDX tumors. HSN608 serves as a valuable tool for researching RET-driven cancers and evaluating therapeutic strategies for mutant RET inhibition.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2234239-90-6
Applications	RET G810 Mutant Inhibitor
Formula	C₂₉H₂₆F₃N₇O
Molecular Weight	545.56
SMILES	O=C(NC1=CC=C(C(C(F)(F)F)=C1)CN2CCN(C)CC2)C3=CC(C#CC4=C5C=CC=NC5=C(N=C4)N)=CN=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.