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Hsp90-Cdc37-IN-1

Hsp90-Cdc37 interaction disruptors

Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptors that inhibit cell migration and reverse drug resistance, with an IC50 of 140 nM.

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Biological Activity

Cellular Effect

Cell Line	Activity	Value	Description	Reference
A549	IC50	4.04 μM	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 29486954]
HCT-116	IC50	7.97 μM	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 29486954]
HepG2	IC50	10.56 μM	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 29486954]
MCF7	IC50	6.37 μM	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 29486954]

Specifications

Manufacturer	Adooq Bioscience
CAS Number	2227303-22-0
Applications	Hsp90-Cdc37 interaction disruptors
Formula	C₄₃H₅₇FN₂O₆S
Molecular Weight	748.99
SMILES	C[C@@]1(C(OCC)=O)C[C@]2([H])[C@](CC[C@]([C@@]3(C)[C@@]4([H])[C@]5(C)[C@@](C(C)(C)[C@@H](OC(CCC(NC6=NC7=C(C=C(F)C=C7)S6)=O)=O)CC5)([H])CC3)(C)C2=CC4=O)(C)CC1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.