HTL14242 is an advanced, orally active negative allosteric modulator (NAM) of the metabotropic glutamate receptor 5 (mGlu5). With a pKi of 9.3 and a pIC50 of 9.2, HTL14242 demonstrates significant binding affinity, making it a valuable tool for exploring the role of mGlu5 modulation in neurological disorders. This compound is particularly relevant for research investigating the therapeutic potential in Parkinson's disease.
HTL14242 is an advanced, orally active negative allosteric modulator (NAM) of the metabotropic glutamate receptor 5 (mGlu5). With a pKi of 9.3 and a pIC50 of 9.2, HTL14242 demonstrates significant binding affinity, making it a valuable tool for exploring the role of mGlu5 modulation in neurological disorders. This compound is particularly relevant for research investigating the therapeutic potential in Parkinson's disease.
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