Fig. 1 · Structure
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HTL14242
mGlu5 NAM
HTL14242 is an advanced, orally active negative allosteric modulator (NAM) of the metabotropic glutamate receptor 5 (mGlu5). With a pKi of 9.3 and a pIC50 of 9.2, HTL14242 demonstrates significant binding affinity, making it a valuable tool for exploring the role of mGlu5 modulation in neurological disorders. This compound is particularly relevant for research investigating the therapeutic potential in Parkinson's disease.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1644645-32-8 |
| Applications | mGlu5 NAM |
| Formula | C16H8ClFN4 |
| Molecular Weight | 310.71 |
| Synonyms | HTL0014242 |
| SMILES | N#CC1=CC(C2=NC=NC(C3=NC=C(F)C=C3)=C2)=CC(Cl)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.