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Hydrohydrastinine

α4β2 Nicotinic Acetylcholine Receptor Antagonist

Hydrohydrastinine is a selective antagonist of the α4β2 nicotinic acetylcholine receptor, displaying an IC50 of 2.6 μM and a Ki of 17 μM. It shows minimal activity against α4β4 and α3β4 receptors. This compound is applicable in studies investigating depression and related neurological disorders, making it a valuable tool for understanding nicotinic signaling pathways in therapeutic contexts.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	494-55-3
Applications	α4β2 Nicotinic Acetylcholine Receptor Antagonist
Formula	C₁₁H₁₃NO₂
Molecular Weight	191.23
SMILES	O1C=2C=C3C(=CC2OC1)CCN(C)C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.