Hydrouracil-3-PhOH

Catalog No.: A80707
Ligand for E3 Ligase
Hydrouracil-3-PhOH is a ligand targeting the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of cereblon to specific target proteins, enabling the construction of proteolysis-targeting chimeras (PROTACs) when conjugated with an appropriate target protein ligand through a linker. This compound is valuable for research applications in protein degradation and modulation of cellular pathways.
Grouped product items
Size Price Stock Qty
25mg
$30.00
In stock
50mg
$50.00
In stock
100mg
$75.00
In stock
250mg
$150.00
In stock
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
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Nature volume 551, pages639-643 (2017)
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Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionHydrouracil-3-PhOH is a ligand targeting the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of cereblon to specific target proteins, enabling the construction of proteolysis-targeting chimeras (PROTACs) when conjugated with an appropriate target protein ligand through a linker. This compound is valuable for research applications in protein degradation and modulation of cellular pathways.
Product Information
Catalog NumA80707
FormulaC10H10N2O3
Molecular Weight206.20
CAS Number1310680-01-3
SMILESO=C1NC(=O)CCN1C=2C=CC=C(O)C2
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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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