Fig. 1 · Structure
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Hydrouracil-3-PhOH
Ligand for E3 Ligase
Hydrouracil-3-PhOH is a ligand targeting the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of cereblon to specific target proteins, enabling the construction of proteolysis-targeting chimeras (PROTACs) when conjugated with an appropriate target protein ligand through a linker. This compound is valuable for research applications in protein degradation and modulation of cellular pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1310680-01-3 |
| Applications | Ligand for E3 Ligase |
| Formula | C10H10N2O3 |
| Molecular Weight | 206.20 |
| SMILES | O=C1NC(=O)CCN1C=2C=CC=C(O)C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.