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Hydrouracil-4-Iodophenyl

Ligand for E3 Ligase

Hydrouracil-4-Iodophenyl is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this essential protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC), enabling selective degradation of specific proteins. It is a valuable tool for studies investigating protein turnover and therapeutic applications in various diseases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	1528991-21-0
Applications	Ligand for E3 Ligase
Formula	C₁₀H₉IN₂O₂
Molecular Weight	316.10
SMILES	O=C1NC(=O)CCN1C2=CC=C(I)C=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.