Fig. 1 · Structure
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Hydroxybupropion
Bupropion Metabolite
Hydroxybupropion is the primary active metabolite of the atypical antidepressant and smoking-cessation agent bupropion. It is primarily metabolized by the CYP2B6 enzyme and functions as an inhibitor of norepinephrine uptake, with an IC50 value of 1.7 μM. Additionally, hydroxybupropion acts as an antagonist at nicotinic acetylcholine receptors, contributing to its pharmacological profile. This compound serves as a valuable tool in research exploring depression, smoking cessation, and the pharmacokinetics of bupropion-derived therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 92264-81-8 |
| Applications | Bupropion Metabolite |
| Formula | C13H18ClNO2 |
| Molecular Weight | 255.74 |
| SMILES | CC(NC(C)(C)CO)C(C1=CC=CC(Cl)=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.