Fig. 1 · Structure
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Hydroxymethyl dasatinib
Dasatinib Metabolite
Hydroxymethyl dasatinib is a significant metabolite of Dasatinib, functioning primarily as a kinase inhibitor. It demonstrates biological activity with an IC50 of 46.7 nM in K562 chronic myeloid leukemia (CML) cells, indicating potent inhibitory effects on cell proliferation. This compound is applicable in research investigating the metabolic pathways of Dasatinib and its efficacy in targeting CML cells.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 910297-58-4 |
| Applications | Dasatinib Metabolite |
| Formula | C22H26ClN7O3S |
| Molecular Weight | 504.00 |
| SMILES | O=C(NC1=C(C=CC=C1Cl)CO)C2=CN=C(S2)NC3=CC(N4CCN(CC4)CCO)=NC(C)=N3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.