Fig. 1 · Structure
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I-138
USP1-UAF1 Inhibitor
I-138 is a potent, orally active, reversible inhibitor of the USP1-UAF1 complex, with an IC50 of 4.1 nM and a Ki of 5.4 nM. This compound effectively induces monoubiquitination of key proteins, such as FANCD2 and PCNA, thereby modulating cellular responses to DNA damage. Its mechanism supports research in DNA repair pathways and the regulation of protein degradation, making I-138 a valuable tool for investigating therapeutic strategies in cancer biology and cellular stress responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2098211-50-6 |
| Applications | USP1-UAF1 Inhibitor |
| Formula | C26H23F3N6O |
| Molecular Weight | 492.50 |
| SMILES | O=C1NC2=CN=C(C3=CC=CC=C3C(C)C)N=C2N1CC4=CC=C(C5=NC(C(F)(F)F)=CN5C)C=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.