Fig. 1 · Structure
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IACS-52825
MAP3K Inhibitor
IACS-52825 is a potent and selective inhibitor of MAP3K (DLK) with an observed Kd of 1.3 nM. This compound demonstrates significant potential in modulating pathways associated with chemotherapy-induced peripheral neuropathy. IACS-52825 is invaluable for research applications focused on neuroprotection and understanding the molecular mechanisms underlying peripheral nerve damage.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2640376-72-1 |
| Applications | MAP3K Inhibitor |
| Formula | C16H13F7N4O2 |
| Molecular Weight | 426.29 |
| SMILES | NC1=NC=C(C=C1OC(F)(F)F)C2=CN(C([C@@H](O)C(F)(F)F)=N2)C34CC(C3)(C4)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.