Ibetazol is an importin β1 (KPNB1) inhibitor that covalently binds to Cys585 of importin β1, thereby blocking importin β1-mediated nuclear import. It exhibits an EC₅₀ of 6.1 µM in cellular assays.
Ibetazol is an importin β1 (KPNB1) inhibitor that covalently binds to Cys585 of importin β1, thereby blocking importin β1-mediated nuclear import. It exhibits an EC₅₀ of 6.1 µM in cellular assays.
Product Information
Catalog Num
A24520
Formula
C13H11F3N2OS
Molecular Weight
300.30
CAS Number
nan
SMILES
FC(F)(F)C1=CC(C2=CC=CC=C2)=NC(S(CC)=O)=N1
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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