Fig. 1 · Structure
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Ibuzatrelvir
Virul protease Inhibitor
Ibuzatrelvir is a second-generation, orally bioavailable inhibitor targeting the main protease (Mpro and 3CLpro) of SARS-CoV-2. This compound exhibits significant antiviral activity against a range of human coronaviruses and demonstrates a favorable off-target selectivity in vitro and in preclinical studies. Additionally, Ibuzatrelvir maintains a safety profile comparable to placebo, making it a promising candidate for the inhibition of COVID-19 and prevention of viral transmission in research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2755812-39-4 |
| Applications | Virul protease Inhibitor |
| Formula | C21H30F3N5O5 |
| Molecular Weight | 489.49 |
| Synonyms | PF-07817883 |
| SMILES | COC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)C(F)(F)F)C(N[C@H](C#N)C[C@H]2C(NCC2)=O)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.