Fig. 1 · Structure
Documents & Downloads
ICCB-19 hydrochloride
TRADD Inhibitor
ICCB-19 hydrochloride is a selective inhibitor of TRADD (TNFRSF1A associated via death domain), targeting its N-terminal domain (TRADD-N) to disrupt interactions with TRADD-C and TRAF2. This compound serves as an indirect inhibitor of RIPK1 kinase activity, demonstrating the potential to induce autophagy and facilitate the degradation of long-lived proteins. ICCB-19 hydrochloride is valuable in studies investigating cell death mechanisms, inflammation, and neurodegenerative conditions by modulating TRADD-mediated signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1803605-68-6 |
| Applications | TRADD Inhibitor |
| Formula | C12H22ClN3OS |
| Molecular Weight | 291.84 |
| SMILES | O=C(NC1CCCCCC1)CSC2=NCCN2.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.