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ICD inducer-2

Immunogenic Cell Death Inducer

ICD inducer-2 is an immunogenic cell death inducer that targets the colchicine binding site on tubulin, inhibiting its polymerization. This compound demonstrates broad-spectrum antiproliferative effects across various cancer cell lines, significantly affecting cell migration and triggering apoptosis through G2/M phase arrest. Additionally, ICD inducer-2 enhances the infiltration of CD4+ and CD8+ T cells within the tumor microenvironment, while modulating the expression of key apoptotic proteins, including downregulation of Bcl-2 and upregulation of Bax and Bim-1. It has shown efficacy in overcoming paclitaxel resistance in xenograft models, making it a valuable tool for cancer research, particularly in lung carcinoma studies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inducer
CAS Number	3069681-35-9
Applications	Immunogenic Cell Death Inducer
Formula	C₂₂H₁₅N₃O₂S
Molecular Weight	385.44
SMILES	N#CC1=C(NC2=CC(C3=CC=CS3)=CC=C2)C4=CC5=C(C=C4N=C1)OCCO5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.