ICEC0942 HCl

Catalog No.: A16903

CDK7 inhibitor

ICEC0942 HCl

ICEC0942 HCl Chemical Structure

CAS NO. 1805789-54-1

ICEC0942, also known as CT7001, is an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment. It selectively inhibits CDK7, with an IC50 of 40nM; IC50 values for CDK1, CDK2, CDK5 and CDK9 were 45-, 15-, 230- and 30-fold higher.

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Package Price Qty
5 mg
$320.00
10 mg
$520.00
50 mg
$1,600.00
100 mg
$2,500.00
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Biological Activity

ICEC0942, also known as CT7001, is an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment. It selectively inhibits CDK7, with an IC50 of 40nM; IC50 values for CDK1, CDK2, CDK5 and CDK9 were 45-, 15-, 230- and 30-fold higher.
In vitro DMSO 76 mg/mL (176.34 mM)
Water 76 mg/mL (176.34 mM)
Ethanol 13 mg/mL (30.16 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.2 mL 116.01 mL 232.03 mL
0.5 mM 4.64 mL 23.2 mL 46.41 mL
1 mM 2.32 mL 11.6 mL 23.2 mL
5 mM 0.46 mL 2.32 mL 4.64 mL

*The above data is based on the productmolecular weight 430.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16903
Actions Inhibitor
CAS No. 1805789-54-1
Formula C22H31ClN6O
M. Wt 430.98
Purity >98%
Synonyms CT7001
SMILES O[[email protected]]1CNCC[[email protected]@H]1CNC2=NC3=C(C(C)C)C=NN3C(NCC4=CC=CC=C4)=C2.[H]Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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