ICI 169369 free base is a selective and non-competitive antagonist of the 5-HT receptor. This compound effectively diminishes vasopressin responses to insulin-induced hypoglycemia without affecting ACTH, prolactin, or growth hormone release. ICI 169369 also modulates centrally mediated 5-HT activity and has been shown to reduce portal pressure in portal hypertensive models, making it a valuable tool for research in neuroendocrine regulation and vascular physiology.
ICI 169369 free base is a selective and non-competitive antagonist of the 5-HT receptor. This compound effectively diminishes vasopressin responses to insulin-induced hypoglycemia without affecting ACTH, prolactin, or growth hormone release. ICI 169369 also modulates centrally mediated 5-HT activity and has been shown to reduce portal pressure in portal hypertensive models, making it a valuable tool for research in neuroendocrine regulation and vascular physiology.
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