Fig. 1 · Structure
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ICI 186756
Elastase Inhibitor
ICI 186756 is a selective inhibitor of human neutrophil elastase, demonstrating competitive inhibition at the enzyme's active site. This compound effectively reduces elastase activity, which may mitigate enzyme-induced pulmonary alterations and has shown potential in modulating lung lesions in hamsters. Its application is particularly relevant in research on inflammatory lung diseases and therapeutic strategies targeting elastase-related pathologies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 95500-67-7 |
| Applications | Elastase Inhibitor |
| Formula | C33H49N5O9 |
| Molecular Weight | 659.77 |
| SMILES | O=C(N[C@H](C=O)C(C)C)[C@H]1N(C([C@H](C(C)C)NC([C@H](CCCCNC(OCC2=CC=CC=C2)=O)NC(CCC(O)=O)=O)=O)=O)CCC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.