Fig. 1 · Structure
Documents & Downloads
ICI-204448
κ-opioid agonists
ICI-204448 is a κ-opioid receptor agonist that demonstrates limited central nervous system penetration. This compound effectively displaces the binding of the κ-opioid ligand 3H-bremazocine from guinea pig cerebellum membranes. It is valuable for research applications focused on the role of κ-opioid receptors in pain modulation and neuropharmacology studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 121264-04-8 |
| Applications | κ-opioid agonists |
| Formula | C23H27Cl3N2O4 |
| Molecular Weight | 501.83 |
| SMILES | O=C(O)COC1=CC=CC(C(N(C(CC2=CC=C(Cl)C(Cl)=C2)=O)C)CN3CCCC3)=C1.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.