Fig. 1 · Structure
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ICI-D 8731
Angiotensin II Receptor Antagonist
ICI-D 8731 is an angiotensin II receptor antagonist with an IC50 of 0.031 μM. This compound demonstrates significant efficacy in lowering blood pressure in renal hypertensive rat models, making it an essential tool for studying hypertension and cardiovascular diseases. Its rapid and sustained therapeutic effects provide valuable insights into the mechanistic pathways of angiotensin II signaling and its implications in vascular health research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 135015-84-8 |
| Applications | Angiotensin II Receptor Antagonist |
| Formula | C25H22ClN5O |
| Molecular Weight | 443.93 |
| Synonyms | ZD-8731 |
| SMILES | CCC1=NC2=CC=CC=C2C(OCC3=CC=C(C=C3)C4=CC=CC=C4C5=NN=NN5)=C1.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.