Fig. 1 · Structure
Documents & Downloads
Iclepertin
GlyT1 Inhibitor
Iclepertin is a selective and orally active inhibitor of glycine transporter 1 (GlyT1), demonstrating potent inhibition while showing no activity against GlyT2. This compound has significant implications in research related to Alzheimer’s disease and schizophrenia, as it modulates glycine levels in the central nervous system, potentially influencing neurotransmission and cognitive function. Its specificity makes it a valuable tool for investigating the therapeutic potential in various neuropsychiatric disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1421936-85-7 |
| Applications | GlyT1 Inhibitor |
| Formula | C20H18F6N2O5S |
| Molecular Weight | 512.42 |
| Synonyms | BI-425809 |
| SMILES | O=C(C1=C(C=CC(S(C)(=O)=O)=C1)O[C@H](C)C(F)(F)F)N2C[C@]3(C4=NOC(C(F)(F)F)=C4)[C@@](C2)([H])C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.