Fig. 1 · Structure
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ICR-191 dihydrochloride
Acridine Mutagen
ICR-191 dihydrochloride is an acridine mutagen that enhances the DNA binding of Cisplatin, thereby sensitizing cells to its effects. This compound significantly increases the expression of phosphorylated H2AX (γH2AX), particularly in cells undergoing DNA replication. ICR-191 dihydrochloride is a valuable tool for studying mechanisms in leukemia research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 17070-45-0 |
| Applications | Acridine Mutagen |
| Formula | C19H23Cl4N3O |
| Molecular Weight | 451.22 |
| SMILES | ClC1=CC2=NC(C=CC(OC)=C3)=C3C(NCCCNCCCl)=C2C=C1.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.