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- Wei Y, .et al. SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage, Mol Cell, 2017, Jun 1;66(5):581-596.e6 PMID: 28552615
Biological Activity
Idarubicin is an anthracycline antibiotic that is an anti-leukemia agent with higher DNA binding capacity and greater cytotoxicity than daunorubicin.
Targets
| Topo II (MCF-7 cells) (Cell-free assay) | Multicellular spheroids (Cell-free assay) | |||
| 3.3 ng/mL | 7.9 ng/mL |
| In vitro | DMSO | 88 mg/mL (164.81 mM) | |
| Water | Warmed: 4 mg/mL (7.49 mM) | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.73 mL | 93.63 mL | 187.27 mL |
| 0.5 mM | 3.75 mL | 18.73 mL | 37.45 mL |
| 1 mM | 1.87 mL | 9.36 mL | 18.73 mL |
| 5 mM | 0.37 mL | 1.87 mL | 3.75 mL |
*The above data is based on the productmolecular weight 534. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10465 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 57852-57-0 |
| Formula | C26H28ClNO9 |
| M. Wt | 534 |
| Purity | >98% |
| Synonyms | Idamycin, Zavedos, 4-demethoxydaunorubicin, DMDR, IMI-30 |
| SMILES | C[[email protected]]1[[email protected]]([[email protected]](C[[email protected]@H](O1)O[[email protected]]2C[[email protected]@](CC3=C(C4=C(C(=C23)O)C(=O)C5=CC=CC=C5C4=O)O)(C(=O)C)O)N)O.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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