Fig. 1 · Structure
Documents & Downloads
Idarubicin
Topo II Inhibitor
Idarubicin is a potent topoisomerase II inhibitor with significant applications in cancer research, particularly in the treatment of leukemias. This anthracycline compound disrupts DNA replication and RNA transcription, leading to DNA damage and inhibition of DNA synthesis. Additionally, idarubicin is known to downregulate c-myc expression, making it a valuable tool for studying oncogenic pathways. Its antimicrobial properties further expand its utility in various biological research contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 58957-92-9 |
| Applications | Topo II Inhibitor |
| Formula | C26H27NO9 |
| Molecular Weight | 497.49 |
| Synonyms | 4-Demethoxydaunorubicin |
| SMILES | OC(C(C(C1=CC=CC=C21)=O)=C3C2=O)=C4[C@H](C[C@@](C(C)=O)(O)CC4=C3O)O[C@@](O[C@@H](C)[C@H]5O)([H])C[C@@H]5N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.