Fig. 1 · Structure
Documents & Downloads
IDB-001
PTC Inhibitor
IDB-001 is a potent inhibitor of the human ribosomal peptidyl transferase center (PTC), disrupting translational elongation through conformational changes induced by specific interactions with Asp/Glu residues in nascent polypeptides. This compound preferentially stalls ribosomes at sites with acidic peptide motifs, leading to cancer cell proliferation inhibition and activation of the integrated stress response via eIF2α phosphorylation at elevated concentrations. Furthermore, IDB-001 can induce ribotoxic stress responses through JNK and p38 phosphorylation. It has been effectively utilized in mechanistic studies of triple-negative breast cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3079913-81-5 |
| Applications | PTC Inhibitor |
| Formula | C19H29N3O4 |
| Molecular Weight | 363.45 |
| SMILES | O=C(NCC[C@@H]1CCCN1)O[C@H]([C@H](CN2)O)[C@H]2CC3=CC=C(C=C3)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.