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Fig. 1 · Structure
Cat. No.
A11707
CAS No.
58186-27-9
Formula
C19H30O5
Mol. Weight
338.44

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Idebenone

Cat. No. A11707 CAS 58186-27-9
Chemically, idebenone is an organic compound of the quinone family. It is also promoted commercially as a synthetic analog of coenzyme Q10 (CoQ10).

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
Fibroblast EC50 592 nM Cytoprotective activity against BSO-induced human FRDA primary patient fibroblasts compound pretreated 12 hrs prior to BSO-induction measured after 48 hrs by calcein-AM-based cell viability assay [PMID: 22137789]
Fibroblast GI50 98 μM Growth inhibition of human FRDA primary patient fibroblasts after 48 hrs by calcein-AM-based cell viability assay [PMID: 22137789]
HepG2 EC50 0.94 μM Suppression of rotenone-induced ATP depletion in human HepG2 cells incubated for 2 hrs by Celltiter-Glo assay [PMID: 33180495]
HepG2 IC50 64.5 μM Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by Celltiter-blue assay [PMID: 33180495]
HL-60 IC50 > 200 μM Antiproliferative activity against human mitochondrial gene-knockout HL60 cells after 48 hrs by MTT assay [PMID: 23432053]
HL-60 IC50 36 μM Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay [PMID: 23432053]
HL-60 IC50 70 μM Inhibition of tPMET complex in human mitochondrial gene-knockout HL60 cells after 30 mins by WST-1/mPMS reduction assay [PMID: 23432053]
HL-60 IC50 77 μM Inhibition of tPMET complex in human HL60 cells after 30 mins by WST-1/mPMS reduction assay [PMID: 23432053]
SH-SY5Y IC50 15.9 μM Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 24 hrs by Celltiter-blue assay [PMID: 33180495]

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Specifications

Manufacturer Adooq Bioscience
CAS Number 58186-27-9
Formula C19H30O5
Molecular Weight 338.44
SMILES
CC1=C(C(=O)C(=C(C1=O)OC)OC)CCCCCCCCCCO

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 60 mg/mL (177.28 mM)
Water Insoluble
Ethanol 60 mg/mL (177.28 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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