Fig. 1 · Structure
Documents & Downloads
IDH2R140Q-IN-1
Cat. No.
A75801
CAS
2469044-23-1
IDH2R140Q Inhibitor
IDH2R140Q-IN-1 is a selective inhibitor of the IDH2R140Q mutant isoform, demonstrating a potent inhibitory effect with an IC50 of 6.1 nM. This compound is primarily utilized in research focused on acute myeloid leukemia, contributing to the understanding of IDH2-driven oncogenesis and potential therapeutic strategies. Its application in preclinical studies may facilitate the development of targeted treatments aimed at malignancies associated with IDH mutations.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2469044-23-1 |
| Applications | IDH2R140Q Inhibitor |
| Formula | C22H20F6N6 |
| Molecular Weight | 482.42 |
| SMILES | FC(C1=CC=CC(C2=NC(NCCCCCC3)=NC(NC4=CC3=CC(C(F)(F)F)=C4)=N2)=N1)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.