Fig. 1 · Structure
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IDH2R140Q-IN-2
Cat. No.
A75800
CAS
2749568-16-7
IDH2 R140Q Mutant Inhibitor
IDH2R140Q-IN-2 is a selective inhibitor targeting the IDH2 R140Q mutant with an IC50 of 29 nM. This compound effectively reduces the production of D2HG in TF-1 cell lines expressing the mutant IDH2 R140Q, demonstrating an IC50 of 10 nM. IDH2R140Q-IN-2 is useful for studying the role of mutant IDH2 in acute myeloid leukemia (AML) and can significantly suppress D2HG levels in tumor tissue.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2749568-16-7 |
| Applications | IDH2 R140Q Mutant Inhibitor |
| Formula | C21H18F6N6O |
| Molecular Weight | 484.40 |
| SMILES | FC(F)(C1=CC(NC2=NC(N3CCC(C3)O)=NC(NC4=CC=CC(C(F)(F)F)=C4)=N2)=CC=C1)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.