IDOR-4

Catalog No.: A66461
CFTR Corrector
IDOR-4 is a type IV CFTR corrector that enhances the trafficking of the F508del-CFTR mutant to the cell surface. This compound is crucial for restoring functional chloride ion transport in cystic fibrosis research and can be utilized to study the dynamics of CFTR correction mechanisms in cellular models. Its application may contribute to the development of therapeutic strategies for patients with cystic fibrosis caused by the F508del mutation.
Grouped product items
Size Price Stock Qty
1mg
$1,160.00
In stock
5mg
$2,995.00
In stock
10mg
$4,915.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionIDOR-4 is a type IV CFTR corrector that enhances the trafficking of the F508del-CFTR mutant to the cell surface. This compound is crucial for restoring functional chloride ion transport in cystic fibrosis research and can be utilized to study the dynamics of CFTR correction mechanisms in cellular models. Its application may contribute to the development of therapeutic strategies for patients with cystic fibrosis caused by the F508del mutation.
Product Information
Catalog NumA66461
FormulaC44H51F3N12O7
Molecular Weight916.95
CAS Number2839901-24-3
SMILESCC1=C2N=CC=CC2=C3C(N[C@@H](CC(N([C@H](C(N([C@@H](C(N[C@@H](COC3=C1)CC4=CC=CC=C4)=O)CC5=NC(C(F)(F)F)=NO5)C)=O)CC(C)C)C)=O)C(NCCN6N=NC(C7CC7)=N6)=O)=O
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