Fig. 1 · Structure
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IgdE protease
Immunoglobulin Degrading Enzyme
IgdE protease is a cysteine protease derived from Streptococcus agalactiae, specifically targeting immunoglobulin G (IgG1) antibodies. This enzyme cleaves mAbs at the upper hinge region, resulting in the generation of Fc/2 and hinge peptide dimers, alongside Fab fragments. IgdE protease is an effective tool for analyzing disulfide bonds and free thiols, as it operates without the need for reducing agents, facilitating more straightforward experimental conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1892548-76-3 |
| Applications | Immunoglobulin Degrading Enzyme |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.