Fig. 1 · Structure
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iGP-1
mGPDH Inhibitor
iGP-1 is a selective mixed inhibitor of mitochondrial sn-glycerol-3-phosphate dehydrogenase (mGPDH) that exhibits IC50 values of 6.3 μM and 13.6 μM for rat mGPDH activity and hydrogen peroxide production, respectively. This compound selectively inhibits the mitochondrial aspect of the glycerophosphate shuttle while leaving cytosolic GPDH unaffected. iGP-1 has demonstrated the ability to inhibit cell proliferation, enhance glycolysis, and alter critical cellular processes, including apoptosis and reactive oxygen species production. It remains effective in neutrophil cultures under both normoxic and hypoxic conditions, making it a valuable tool for investigating glycerol-3-phosphate metabolic pathways in cancer research, particularly in prostate cancer studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 27031-00-1 |
| Applications | mGPDH Inhibitor |
| Formula | C17H15N3O3 |
| Molecular Weight | 309.32 |
| SMILES | O=C(CCC(NC1=CC=C(C=C1)C2=NC3=CC=CC=C3N2)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.