Fig. 1 · Structure
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IHCH-7086
β-arrestin-biased 5-HT2AR Agonist
IHCH-7086 is a partial β-arrestin-biased agonist of the 5-HT2A receptor, exhibiting a Ki value of 12.59 nM, and capable of crossing the blood-brain barrier. This compound has demonstrated effectiveness in blocking D-lysergic acid diethylamide-induced head-twitch responses in murine models and alleviating depression-like behaviors in mice subjected to acute restraint stress or corticosterone administration. IHCH-7086 is particularly relevant for research focused on depression and related neuronal signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2957888-70-7 |
| Applications | β-arrestin-biased 5-HT2AR Agonist |
| Formula | C24H31N3O |
| Molecular Weight | 377.52 |
| SMILES | CN1C2=C3C([C@@]4([H])[C@@](CCN(C4)CCCC5=C(C=CC=C5)OC)([H])N3CC1)=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.