Fig. 1 · Structure
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iHCK-37
Hck Inhibitor
iHCK-37 is a potent and selective inhibitor of the Hck kinase, exhibiting a Ki of 0.22 μM. This compound effectively blocks HIV-1 viral replication, with an EC50 of 12.9 μM, demonstrating its potential in antiviral research. Additionally, iHCK-37 is applicable in studies focused on chronic myeloid leukemia (CML), providing valuable insights into therapeutic strategies targeting Hck.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 516478-09-4 |
| Applications | Hck Inhibitor |
| Formula | C30H32N4O2S2 |
| Molecular Weight | 544.73 |
| Synonyms | ASN05260065 |
| SMILES | O=C(NC1=CC=CC=C1N2CCOCC2)CSC3=C(C4=C(CCCC4)S5)C5=NC(CCC6=CC=CC=C6)=N3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.