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IHMT-IDH1-053

Name: IHMT-IDH1-053
Brand: Adooq Bioscience
SKU: A75802
Availability: OutOfStock

Cat. No. A75802 CAS 3049485-80-2

IDH1-mutant Inhibitor

IHMT-IDH1-053 is a highly selective and irreversible inhibitor of IDH1 R132H mutants, with an IC50 of 4.7 nM. It demonstrates pronounced selectivity against IDH1 wild-type and various IDH2 isoforms. IHMT-IDH1-053 effectively inhibits the production of 2-hydroxyglutarate (2-HG) in IDH1 R132H mutant transfected 293T cells, achieving an IC50 of 28 nM. Additionally, this compound blocks the proliferation of HT1080 cell lines and primary acute myeloid leukemia (AML) cells harboring IDH1 R132 mutants, providing valuable insights for therapeutic target validation in IDH1-mutant driven malignancies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3049485-80-2
Applications	IDH1-mutant Inhibitor
Formula	C₂₅H₃₃FN₆O₄S
Molecular Weight	532.63
SMILES	C[C@H](NC1=NC=C(F)C(N2C(OC[C@@H]2C(C)C)=O)=N1)C3=CC=C(N4CCC(NS(C=C)(=O)=O)CC4)C=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.