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IIIM-290

CDK inhibitor

IIIM-290 is a potent and oral CDK inhibitor with IC50s of 90 and 94 nM for CDK2/A and CDK9/T1.

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Biological Activity

Target & Activity

Target	Activity	Value
CDK2/A	IC50	90 nM
CDK9/T1	IC50	94 nM

Cellular Effect

Cell Line	Activity	Value	Description	Reference
786-0	GI50	6 μM	Growth inhibition of human 786-0 cells after 48 hrs by MTT assay	[PMID: 29370702]
A-431	GI50	8 μM	Growth inhibition of human A431 cells after 48 hrs by MTT assay	[PMID: 29370702]
A549	GI50	4 μM	Growth inhibition of human A549 cells after 48 hrs by MTT assay	[PMID: 29370702]
BT-549	GI50	5 μM	Growth inhibition of human BT549 cells after 48 hrs by MTT assay	[PMID: 29370702]
Caco-2	GI50	7 μM	Growth inhibition of human Caco2 cells after 48 hrs by MTT assay	[PMID: 29370702]
COLO 205	GI50	7 μM	Growth inhibition of human COLO205 cells after 48 hrs by MTT assay	[PMID: 29370702]
DU-145	GI50	5 μM	Growth inhibition of human DU145 cells after 48 hrs by MTT assay	[PMID: 29370702]
HCT-116	GI50	5 μM	Growth inhibition of human HCT116 cells after 48 hrs by MTT assay	[PMID: 29370702]
HEK293	IC50	> 50 μM	Inhibition of [3H]-astemizole binding to human ERG expressed in HEK293 cell membranes by scintillation counting method	[PMID: 29370702]
HEK293	GI50	22 μM	Growth inhibition of human HEK293 cells after 48 hrs by MTT assay	[PMID: 29370702]
HL-60	GI50	0.9 μM	Growth inhibition of human HL60 cells after 48 hrs by MTT assay	[PMID: 29370702]
HOP-62	GI50	7 μM	Growth inhibition of human HOP62 cells after 48 hrs by MTT assay	[PMID: 29370702]
HOP-92	GI50	3 μM	Growth inhibition of human HOP92 cells after 48 hrs by MTT assay	[PMID: 29370702]
LOX IMVI	GI50	4 μM	Growth inhibition of human LOXIMVI cells after 48 hrs by MTT assay	[PMID: 29370702]
MCF7	GI50	4 μM	Growth inhibition of human MCF7 cells after 48 hrs by MTT assay	[PMID: 29370702]
MDA-MB-231	GI50	4 μM	Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 29370702]
MDA-MB-468	GI50	4 μM	Growth inhibition of human MDA-MB-468 cells after 48 hrs by MTT assay	[PMID: 29370702]
MIA PaCa-2	GI50	1 μM	Growth inhibition of human MIAPaCa2 cells after 48 hrs by MTT assay	[PMID: 29370702]
MOLT-4	GI50	0.5 μM	Growth inhibition of human MOLT4 cells after 48 hrs by MTT assay	[PMID: 29370702]
NCI-H226	GI50	4 μM	Growth inhibition of human NCI-H226 cells after 48 hrs by MTT assay	[PMID: 29370702]
NCI-H522	GI50	5 μM	Growth inhibition of human NCI-H522 cells after 48 hrs by MTT assay	[PMID: 29370702]

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2213468-64-3
Applications	CDK inhibitor
Formula	C₂₃H₂₁Cl₂NO₅
Molecular Weight	462.32
SMILES	OC1=C2C(OC(/C=C/C3=C(Cl)C=CC=C3Cl)=CC2=O)=C([C@]4([H])[C@H](O)CN(C)CC4)C(O)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.