IKVAVC is a modified peptide of IKVAV, featuring a cysteine residue at the C-terminus that facilitates covalent conjugation to various molecular platforms. It functions as a neural adhesion and differentiation signaling peptide, preserving the biological activities of IKVAV. IKVAVC inhibits fibroblast migration and activation, downregulates the TGF-β1 signaling pathway and endoplasmic reticulum stress, and supports nerve repair. Additionally, it promotes a phenotypic shift in macrophages from the pro-inflammatory M1 state to the pro-reparative M2 state, thereby enhancing tissue regeneration processes.
IKVAVC is a modified peptide of IKVAV, featuring a cysteine residue at the C-terminus that facilitates covalent conjugation to various molecular platforms. It functions as a neural adhesion and differentiation signaling peptide, preserving the biological activities of IKVAV. IKVAVC inhibits fibroblast migration and activation, downregulates the TGF-β1 signaling pathway and endoplasmic reticulum stress, and supports nerve repair. Additionally, it promotes a phenotypic shift in macrophages from the pro-inflammatory M1 state to the pro-reparative M2 state, thereby enhancing tissue regeneration processes.
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