Fig. 1 · Structure
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IL-6-IN-2
IL-6/IL-6R Protein Interaction Inhibitor
IL-6-IN-2 is a potent inhibitor of the IL-6/IL-6R protein interaction, with a calculated ∆G binding energy of −36.50 kcal/mol. This compound disrupts critical interactions among key residues, including Lys66, Phe74, Gln175, Ser176, and Arg179, contributing significantly to IL-6 binding affinity. IL-6-IN-2 is useful for studying the role of IL-6 signaling in inflammatory diseases and may facilitate research on potential therapeutic interventions targeting this pathway. Its low gastrointestinal absorption profile highlights the need for alternative administration strategies in pharmacological studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 296790-70-0 |
| Applications | IL-6/IL-6R Protein Interaction Inhibitor |
| Formula | C26H24N4O3 |
| Molecular Weight | 440.49 |
| SMILES | OC1=C(C(C2=C(N(C3=CC=CC=C3)N=C2C)O)C4=CC=C(C)O4)C(C)=NN1C5=CC=CC=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.