Fig. 1 · Structure

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ILK-IN-2

ILK inhibitor

ILK-IN-2 (OSU-T315 analog) is a ILK inhibitor.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
LNCaP IC50 1.6 μM Antiproliferative activity against human LNCAP cells assessed as suppression of cell viability by MTT assay [PMID: 21823616]
MCF7 IC50 2.5 μM Antiproliferative activity against human MCF7 cells assessed as suppression of cell viability by MTT assay [PMID: 21823616]
MDA-MB-231 IC50 1 μM Antiproliferative activity against human MDA-MB-231 cells assessed as suppression of cell viability by MTT assay [PMID: 21823616]
MDA-MB-468 IC50 1.5 μM Antiproliferative activity against human MDA-MB-468 cells assessed as suppression of cell viability by MTT assay [PMID: 21823616]
PC-3 IC50 2 μM Antiproliferative activity against human PC3 cells assessed as suppression of cell viability by MTT assay [PMID: 21823616]
SK-BR-3 IC50 1.8 μM Antiproliferative activity against human SKBR3 cells assessed as suppression of cell viability by MTT assay [PMID: 21823616]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 1333146-24-9
Applications ILK inhibitor
Formula C30H30F3N5O
Molecular Weight 533.59
SMILES
O=C(NC)CCC1=NN(C2=CC=C(N3CCNCC3)C=C2)C(C4=CC=C(C5=CC=C(C(F)(F)F)C=C5)C=C4)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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