Fig. 1 · Structure
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Imatinib-d3 hydrochloride
Stable Isotope
Imatinib-d3 hydrochloride is a deuterium-labeled derivative of Imatinib, a potent inhibitor of tyrosine kinases. It selectively targets BCR/ABL, PDGFR, and c-kit, effectively inhibiting their enzymatic activity by binding near the ATP binding site and maintaining a closed conformation. This unique stable isotope can be utilized in pharmacokinetic studies and metabolic profiling, aiding research on drug metabolism and biomarkers. Additionally, Imatinib exhibits inhibitory effects on SARS-CoV and MERS-CoV, making it relevant for investigations into viral inhibition mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1134803-18-1 |
| Applications | Stable Isotope |
| Formula | C29H28D3N7O |
| Molecular Weight | 496.62 |
| Synonyms | STI571-d3 hydrochloride; CGP-57148B-d3 hydrochloride |
| SMILES | O=C(C1=CC=C(C=C1)CN2CCN(CC2)C([2H])([2H])[2H])NC3=CC=C(C)C(NC4=NC=CC(C5=CN=CC=C5)=N4)=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.