Fig. 1 · Structure
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Imipramine
Antidepressant
Imipramine is a tricyclic antidepressant that primarily targets serotonin transporters, exhibiting an IC50 value of 32 nM. In addition to its antidepressant properties, Imipramine acts as a Fascin1 inhibitor, displaying antitumor activity. This compound promotes autophagy in U-87MG glioma cells and induces apoptosis in HL-60 cells. Furthermore, Imipramine has demonstrated neuroprotective and immunomodulatory effects, making it valuable for research in neurobiology and cancer therapy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 50-49-7 |
| Applications | Antidepressant |
| Formula | C19H24N2 |
| Molecular Weight | 280.41 |
| SMILES | CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.