Fig. 1 · Structure
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IMPDH-IN-4
Anticancer Compound
IMPDH-IN-4 is an inosine monophosphate dehydrogenase (IMPDH) inhibitor designed for research in anticancer applications. It demonstrates significant activity against peripheral nerve sheath carcinoma cells by increasing the accumulation of inosine monophosphate within these cells. Additionally, this compound can effectively cross the blood-brain barrier, making it suitable for studies focused on both central and peripheral nervous system cancers. Its unique mechanism of action, involving metabolism by NAMPT and NMNAT1 to form an adenine dinucleotide derivative, positions IMPDH-IN-4 as a valuable tool for cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2427862-70-0 |
| Applications | Anticancer Compound |
| Formula | C10H8N2OS |
| Molecular Weight | 204.25 |
| SMILES | O=C(NC1=CC=CS1)C2=CN=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.