Fig. 1 · Structure
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Inaxaplin
APOL1 Function Inhibitor
Inaxaplin is an orally active inhibitor of apolipoprotein L1 (APOL1) function. It is primarily utilized in research focused on kidney disease, particularly in understanding the role of APOL1 in renal pathology. This compound provides a valuable tool for investigating the mechanisms underlying APOL1-related disorders and potential therapeutic approaches.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2446816-88-0 |
| Applications | APOL1 Function Inhibitor |
| Formula | C21H18F3N3O3 |
| Molecular Weight | 417.38 |
| Synonyms | VX-147 |
| SMILES | O[C@H](CNC1=O)[C@@H]1NC(CCC(C2=CC(F)=C3)=C(C4=CC=C(C=C4)F)NC2=C3F)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.