Fig. 1 · Structure
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Incadronate disodium
Cholesterol-Lowering Agent
Incadronate disodium is a bisphosphonate that serves as a cholesterol-lowering agent by inhibiting rat liver microsomal squalene synthase with a Ki of 57 nM. It also has demonstrated the ability to suppress sterol biosynthesis in mouse macrophage J774 cells, exhibiting an IC50 of 64 μM. Additionally, this compound may have potential applications in the research of malignant tumors through its indirect stimulation of renal 25-hydroxyvitamin D-1-hydroxylase by elevating circulating parathyroid hormone.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 138330-18-4 |
| Applications | Cholesterol-Lowering Agent |
| Formula | C8H17NNa2O6P2 |
| Molecular Weight | 331.15 |
| Synonyms | YM 175; Bisphonal |
| SMILES | O=P(C(P(O)(O[Na])=O)NC1CCCCCC1)(O[Na])O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.