Fig. 1 · Structure
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INCB3619
ADAM Inhibitor
INCB3619 is a selective and orally active inhibitor of ADAM metalloproteinases, demonstrating an IC50 of 22 nM for ADAM10 and 14 nM for ADAM17. This compound exhibits notable anti-tumor activity, making it a valuable tool for cancer research. INCB3619 is applicable in studies exploring the roles of ADAM proteases in tumor progression and metastasis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 791826-72-7 |
| Applications | ADAM Inhibitor |
| Formula | C22H27N3O5 |
| Molecular Weight | 413.47 |
| SMILES | O=C(N([C@H](C(N1CC=C(C2=CC=CC=C2)CC1)=O)[C@@H](C(NO)=O)C3)CC43CC4)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.