Fig. 1 · Structure
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INCB38579
HH4R Antagonist
INCB38579 is a selective antagonist of the histamine H4 receptor (HH4R), exhibiting potent inhibition with an IC50 of 4.8 nM for the human receptor. This compound demonstrates significant anti-inflammatory and anti-pruritic activities, making it a valuable tool in research focused on allergy, inflammation, and pain modulation. Its oral bioavailability and high brain penetrability further enhance its utility in neurobiological studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1246207-65-7 |
| Applications | HH4R Antagonist |
| Formula | C25H34N6O |
| Molecular Weight | 434.58 |
| SMILES | O=C(CC1CCCC1)N2CCC3=CC=C(C4=NC(N)=NC(N5CCN(C)CC5)=C4)C=C3C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.